RNA-based transcription regulation
Abstract
Our laboratory uses a combination of integrated structural biology, biochemistry, and functional genomics, to unravel the mechanisms of gene transcription in eukaryotes. In this talk I will first summarize our current molecular-mechanistic understanding of transcription and will then concentrate on the role of RNA in coordinating and regulating transcription. I will also present how we envision to develop the new field of molecular systems biology to study gene regulation globally.
References
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D. Kostrewa, M.E. Zeller, K.J. Armache, M. Seizl, K. Leike, M. Thomm, and P. Cramer.
RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature 2009, 462, 323-330.
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Molecular basis of RNA-dependent RNA polymerase II activity.
Nature 450, 445-449 (2007).
