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List of Abstracts

Mitochondrial Presequence Translocase And Respiratory Chain Complexes – An Intimate Liaison
Invited Speaker
Membrane Biology
Mitochondrial proteins are generally synthesized in the cytosol and subsequently imported into the organelle. The TIM23 machinery mediates sorting of preprotein at the inner mitochondrial membrane. We study how TIM23 cooperates with different partner protein complexes to assure precise and efficient targeting of preproteins to the destined compartment.
Optimization of cultural conditions for biosynthesis, partial purification and characterization of Invertase by Aspergillus species
Poster
Other (free) Topics
Strain improvement and genetic characterization of Alternaria tenuissima FCBP-252 for hyper-active α-amylase
Poster
Other (free) Topics
Annotating New Genes: From In Silico Screening to Validations by Experiments
Poster and application for short presentation
Chemical and Systems Biology
Glucose and related sugars are allosteric potentiators of glycine receptor-mediated signaling
Poster and application for short presentation
Molecular Medicine
Glucose and other saccharides were identified as allosteric modulators of glycine receptor-mediated responses. This is relevant for experimental work, as glucose is often added to electrophysiology buffers and may account for some of the variations in published constants. Also, we observe glucose-mediated effects at concentrations observed in some diseases, or with anesthetic fluids, indicating that modulation of synaptic receptors by sugars is a medically relevant parameter.
Purification and Crystallization of the His-tagged AIDA-I ß-barrel in the outer membrane of E. coli
Poster
Protein Structure and Dynamics
Conformational assessment of human hemoglobin during iron induced oxidative stress.
Poster and application for short presentation
Molecular Medicine
Insights into the Conformational Changes of human hemoglobin during iron catalyzed oxidation.
Molecular Functionality of the Urophatogenic RTX Toxin Haemolysin A from E. coli
Poster
Protein Structure and Dynamics
Functional impact of COP9 signalosome and DEN1 interaction
Poster
Other (free) Topics
Development of a Novel System for Building Artificial Enantioselective Catalysts
Poster and application for short presentation
Protein Structure and Dynamics
Cyanobacterial CRISPR-Cas systems, an archaeal-bacterial hybrid?
Poster and application for short presentation
RNA Biology
Biogenesis of αlpha-helical outer membrane proteins
Poster and application for short presentation
Membrane Biology
The Balance Model explains Ras-Isoform Specificity by Sequence Variations on Helix alpha-4 and the Hypervariable Region
Poster and application for short presentation
Protein Structure and Dynamics
We have shown that the small GTPase Ras has a third switch region, which is associated with a novel membrane reorientation mechanism of Ras.
Targeting and activation of the AAA+ chaperone ClpB by cooperating Hsp70 during protein disaggregation
Poster and application for short presentation
Protein Structure and Dynamics
The Unfolded Protein Response in Health and Disease
Invited Speaker
Mechanisms of mitochondrial redox signaling
Invited Speaker
Other (free) Topics
Kinetic studies of Partially Purified Cellulases of Trichoderma viride FCBP-142 and its Hyperactive Mutants
Poster
Other (free) Topics
A new Bioactive Annuionone from sunflower leaves
Poster and application for short presentation
Chemical and Systems Biology, Other (free) Topics
A new bioactive Annuionone was reported from leaf extract of sunflower variety Suncross-42. this extact was found effective in weed management in wheat fields.
Autophagy: a cytoprotective mechanism with anti-aging properties
Invited Speaker
Molecular Medicine
Invited plenary lecture
Two novel mutations in hMLH1 gene in Iranian hereditary non-polyposis colorectal cancer patients
Poster
Molecular Medicine
Mutation detection in hMLH1 gene in HNPCC patients in Isfahan Iran
PROTEASE DEGRADOMICS STUDIED USING POSITIONAL PROTEOMICS
Invited Speaker
Other (free) Topics
Chaperones for membrane protein biosynthesis and quality control
Invited Speaker
Membrane Biology
Modelling Bacterial metabolism: Smooth adaptation to different conditions
Invited Speaker
Chemical and Systems Biology
A network perspective on the biology of ageing
Invited Speaker
Other (free) Topics
This presentation will discuss the use of molecular networks to better understand the causes and consequences of ageing.
A New Probabilistic Approach in Predictive Microbiology
Poster and application for short presentation
Other (free) Topics
Characterisation of the human Multidrug resistence Protein 3
Poster
Other (free) Topics
The main aim of my work is to show the function of the human multidrug resistence protein 3 (MDR3) in vitro. Therefor I expressed MDR3 in Pichia pastoris and purified MDR3 with affinity chromatography. The first functional assays point out that MDR3 translocates phosphatidylcholine (PC).
Real-time analysis of siRNA integrity and distribution
Poster
Other (free) Topics
Double labeled siRNA is used to analyze the integrity level and distribution of duplex siRNA in living cells.
Modification of Antibody Disulfide Bonds with Maleimides
Poster and application for short presentation
Chemical and Systems Biology
The site-specific modification of antibody fragments and full antibodies via their disulfide bonds is demonstrated. The one-pot reaction is fast, high yielding and reversible and the modified proteins retain full activity.
Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling
Poster and application for short presentation
Protein Structure and Dynamics
Synaptic vesicle recycling: Molecular functions of the AP-1 complex subunit σ1B-adaptin
Poster
Membrane Biology, Other (free) Topics
Cryo-electron tomography of Marburg virus particles and their assembly and release from infected cells
Poster
Membrane Biology, Protein Structure and Dynamics
Structure and assembly mechanism of a filovirus was described using a hybrid methodology of Cryo-electron microscopy (cryoEM), cryo-electron tomography (cryoET) and immuno-electron microscopy. CryoET of viral budding intermediates revealed differences between filoviruses and rhabdoviruses (rabies virus, vesicular stomatitis virus).
Proteolytic processing of the type II transmembrane serine protease matriptase-2, the key regulator of iron homeostasis
Poster and application for short presentation
Protein Structure and Dynamics
Insights into matriptase-2 substrate binding and inhibition mechanisms
Poster
Protein Structure and Dynamics
Diffusion and interactions in micropatterned and phase-separated polymer-supported membranes
Poster and application for short presentation
Membrane Biology
Evolutionary Optimization of Cyclic Peptides for Protease Inhibition
Poster
Chemical and Systems Biology
Nicole Albrecht, Katharina Berger, Nadja Bjelopoljak, Leif Blaese, Nadine Böhmer, Jessica Eger, Sebastian Hanke1, Sandrina Heyde, Paul Kaufmann1, Sabine Meyer, Sascha Ramm, Stefanie Sempert, Stefan Wahlefeld, Niels Weisbach, Tobias Wenzel,Elke Dittmann, Katja Arndt, Kristian Müller
Import of Copper chaperone for SOD1 (Ccs1) to inter-membrane space of mitochondria
Poster and application for short presentation
Other (free) Topics
We investigated the detailed machanism that imports Ccs1 into inter-membrane space of mitochondira and characterized its interaction with Mia40.
Flotillin-1 is essential for the activation of EGF receptor
Poster and application for short presentation
Signaling – from Membranes to Nucleus
Differential glycomics of epithelial membrane glycoproteins from urinary exovesicles reveals shifts towards complex-type N-glycosylation in classical galactosemia
Poster and application for short presentation
Molecular Medicine, Other (free) Topics
A glycosylation shift in N-glycans, from high-mannose-type to complex-type, on urinary exosomes could be detected in classical galactosemia
What’s behind the dot? - Holistic Content Analysis of the Paraspeckle Complex -
Poster
Protein Structure and Dynamics, Signaling – from Membranes to Nucleus, RNA Biology
We are investigating the full protein- and RNAome of a nuclear mega complex - The Parasepckle. This will be the key to further understanding of the paraspeckular mechanisms and its underlying functions.
Playing Lego: A functional protein designed from fragments of two different folds
Poster and application for short presentation
Other (free) Topics
We demonstrate the evolutionary concept of fragment recruitment by rationally designing a functional protein from fragments of two different folds.
Analysis of protein structure topologies by graph theoretical methods
Poster
Protein Structure and Dynamics
The PTGL, a database which describes protein structure on the super-secondary level using graphs, has been extended with ligand information. A desktop program which can be used to visualize protein graphs has also been implemented.
Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex
Poster and application for short presentation
Protein Structure and Dynamics
PLEASE NOTE: this data complements those that are going to be presented by Simon Reitz (Sinning group, Heidelberg). Thus, it would be great if posters could be placed next to each other.
The GroEL/GroES chaperonin ring machine
Invited Speaker
Protein Structure and Dynamics
The GroEL/GroES machine mediates folding of many proteins to the native state. New studies are presented of the action of ATP in driving the reaction, and experiments on the action of the GroES-encapsulated folding chamber are presented
Lectin-glycan binding controls axon-myelin interactions
Invited Speaker
Other (free) Topics
Myelin-associated glycoprotein on the innermost myelin wrap binds specifically to sialylated glycolipids (gangliosides) on the apposing axon surface to mediate axon-myelin stability and regulate axon regeneration after injury.
SUBSTRATE RECOGNITION AND SPECIFICITY OF NISB, THE LANTIBIOTIC DEHYDRATASE INVOLVED IN NISIN BIOSYNTHESIS
Poster
Other (free) Topics
GFP-tagging sheds light on protein translocation
Poster and application for short presentation
Protein Structure and Dynamics, Other (free) Topics
Cell-free expression & assembly of a macromolecular membrane protein complex: a complete ATP synthase
Poster and application for short presentation
Membrane Biology, Protein Structure and Dynamics, Chemical and Systems Biology
- cell-free expression - transcription and translation - protein synthesis - protein folding and complex assembly - biochemical and structural analyses
Tic110 and Tic20: multiple translocation channels at the Tic Translocon?
Poster and application for short presentation
Protein Structure and Dynamics
The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signaling in the intestinal epithelium
Poster
Other (free) Topics
MALDI in-situ mass spectrometry of renal sulfatides
Poster
Membrane Biology
Arrestin-related proteins mediate Plasma Membrane Protein Quality Maintenance in Yeast
Invited Speaker
Membrane Biology
How the Endoplasmic Reticulum Gets Into Shape
Invited Speaker
Molecular Medicine, Membrane Biology, Protein Structure and Dynamics
Structural and functional analysis of the AAA ATPase Bl-ARC from Bifidobacterium longum
Poster
Chemical and Systems Biology
Heterologous expression and characterization of a Superoxide Dismutase from the archeon Thermoplasma acidophilum
Poster
Chemical and Systems Biology
In-depth Analysis of Proteasomal Assembly and Diversity in Eukaryotes
Invited Speaker
Protein Structure and Dynamics
The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient, and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells. The highly organized proteasome plays a prominent role in the control of a diverse array of basic cellular activities by rapidly and unidirectionally catalyzing biological reactions. Studies of the proteasome during the past quarter of a century have provided profound insights into its structure and functions.
A cytosolic redox enzyme in ER-associated degradation
Invited Speaker
Other (free) Topics
Quantitative Automated Mircroscopy (QuAM) elucidates growth factor specific signaling in pain sensitization
Poster and application for short presentation
Signaling – from Membranes to Nucleus
Flotillin-2 regulates the dynamics of focal adhesions by interacting with alpha-actinin and influencing FAK phosphorylation
Poster
Signaling – from Membranes to Nucleus
Spying on drugs and metabolites in living cells
Invited Speaker
Chemical and Systems Biology
The need for proton-driven vesicular Cl- accumulation: insights from human disease, designer mice and biophysics
Invited Speaker
Molecular Medicine
Localization and function of ubiquinone-8 in the Na+ -pumping NADH:Quinone oxidoreductase from Vibrio cholerae
Poster
Membrane Biology
A central player in the sodium ion cycle across the inner bacterial membrane of the human pathogen Vibrio cholerae is the Na+-pumping NADH:quinone oxidoreductase (Na+-NQR), which transports Na+ ions upon the oxidation of NADH by ubiquinone (Q). The Na+ -NQR is a respiratory NADH dehydrogenase which is not related to complex I of mitochondria or bacteria.
Chemical Control of Intracellular Signaling Cascades in Time and Space
Poster and application for short presentation
Chemical and Systems Biology
O-Linked LacdiNAc-Modified Glycans in Extracellular Matrix Glycoproteins are Specifically Phosphorylated in a Cell Stress Independent Manner
Poster and application for short presentation
Other (free) Topics
Novel type of mucin-type O-glycan modification: phosphorylation of LacdiNAc
The antimicrobial peptide LL-37 stabilizes neutrophil extracellular traps against Staphylococcus areus nuclease degradation
Poster
Other (free) Topics
Neural crest cell induction and cell shape changes on biofunctionalized lipid bilayers
Poster
Membrane Biology
Initial recognition steps of a Type 1 secretion system
Poster and application for short presentation
Elucidating the mode of action of gephyronic acid
Poster and application for short presentation
Chemical and Systems Biology
DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population
Poster
Molecular Medicine, Other (free) Topics
Synaptic signal complexes of metabotropic glutamate receptors: mGluR8 interacts with SUMO ligases and Band 4.1 proteins
Poster and application for short presentation
Signaling – from Membranes to Nucleus
O-Linked LacdiNAc-modified glycans in extracellular matrix glycoproteins are glycan-specifically phosphorylated in a cell stress independent manner
Poster and application for short presentation
Other (free) Topics
Phosphorylation of LacdiNAc termini in O-glycans
Structural characterization of the mammalian autophagy conjugation systems Atg12-Atg5 and LC3
Poster and application for short presentation
Protein Structure and Dynamics
Molecular mechanisms of GlyT2 mutations in startle disease
Invited Speaker
Other (free) Topics
An update on the molecular genetics of startle disease mutations in glycine transporter genes
Characterisation of RPGR and RPGR-IP in the ciliary network
Poster
Protein Structure and Dynamics
Sirt3 - A stress regulator of OXPHOS function and mitochondrial translation
Poster and application for short presentation
Molecular Medicine, RNA Biology, Other (free) Topics
Spore Photoproduct Lyase and its Substrate in double stranded Oligonucleotides
Poster
Other (free) Topics
Here we describe enzymatic properties of the spore photoproduct lyase, a member of the radical SAM family of enzymes. It repairs the spore photoproduct, a UV-induced DNA lesion, by using radical chemistry. To gain information about base pairing and duplex distortion properties, the lesion was furthermore co-crystallized with a polymerase.
A specific function of ER glucosylation enzymes in gastrulation of Drosophila embryos
Poster
Other (free) Topics
Improved sensitivity in mass spectrometric quantification of serum growth hormone (GH) by amphiphilic conjugation
Poster and application for short presentation
Chemical and Systems Biology
A sensitive isotope dilution mass spectrometry based method for growth hormone quantification has been developed. The sensitivity of the method has been improved by conjugation of the analyte with an amphiphilic reagent, which increases the electrospray ionization response.
The „Compressed Sensing“ of neuronal morphology
Poster
Other (free) Topics
Enzymatic Activity of Prolyl-4-Hydroxylase PHD2 is predominantly effective in the nucleus
Poster and application for short presentation
Signaling – from Membranes to Nucleus
Putative nuclear transport signals were identified in the primary sequence of Prolyl-4-Hydroxylase PHD2. The intracellular localisation of PHD2 plays a critical role for the regulation of the HIF-1 signalling pathway.
Bacterial Pathogens and their Pan-Proteome - From Next-Generation Sequencing to Target Identification
Poster
Other (free) Topics
Molecular Origami: protein folding and misfoldng in health and disease.
Invited Speaker
Protein Structure and Dynamics
Sym1 forms a channel in the inner mitochondrial membrane
Poster
Protein Structure and Dynamics
A systematic microscopy screen uncovers the insertion requirement of yeast mitochondrial tail-anchored proteins
Poster
Membrane Biology
Intestinal miR-29a targets Caveolin-2
Poster
RNA Biology
The Cytochrome c Oxidase subunit Cox26 participates in late steps of complex assembly
Poster
Protein Structure and Dynamics
Molecular functions of the most conserved ABC-protein within ribosome recycling
Poster
Protein Structure and Dynamics, RNA Biology
Fluorescence-based analysis of single membrane protein transport kinetics on nanopore arrays
Poster
Chemical and Systems Biology
CRISPR-Cas with a grain of salt
Poster
RNA Biology
The transport mechanism of the multidrug transporter AcrB involves two binding areas that are seperated by a switch-loop
Poster and application for short presentation
Membrane Biology, Protein Structure and Dynamics
The ATP synthase: the understood, the uncertain and the unknown
Invited Speaker
Membrane Biology
Vasostatin_Vasoinhibin: a novel fusion protein that inhibits the proliferation of endothelial cells
Poster
Chemical and Systems Biology
design and production of a fusion protein between the vasostatin and vasoinhibin to get a protein with high anti-angiogenic activity
Understanding Marinesco-Sjögren Syndrome using Quantitative Proteomics
Poster
Other (free) Topics
Utilizing Endogenous MicroRNA Expression for Oncolytic Virotherapy
Poster and application for short presentation
Other (free) Topics
This presentation is held to support my PhD defense
Application of “click chemistry” to 5-bromo-2’-deoxyuridine (Br-dU)
Poster
Other (free) Topics
Investigation of the mechanism of Brr2-mediated dissociation of U4/U6 di-snRNAs
Poster
RNA Biology
Targeting of histone deacetylase 10 causes neuroblastoma cell death via lysosomal dysfunctions and ROS release
Poster and application for short presentation
Molecular Medicine
Biochemical and structural characterization of the chloroplast signal recognition particle
Poster and application for short presentation
Protein Structure and Dynamics
Identification of antigenic determinants on growth hormone by mass spectrometry
Poster and application for short presentation
Protein Structure and Dynamics
Regulation of SUMO enzymes by oxidative stress
Invited Speaker
Other (free) Topics
GBM-Studiengruppe "Redoxbiologie"
Increased polysialylation in lung tissue of patients with Idiopathic Pulmonary Fibrosis
Poster and application for short presentation
Other (free) Topics
Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast
Poster
Membrane Biology
The secreted catalase PaCATB modulates lifespan of Podospora anserina under oxidative stress
Poster
Other (free) Topics
The Get3-receptor complex in tail-anchored membrane protein targeting
Poster and application for short presentation
Protein Structure and Dynamics
PLEASE NOTE: this abstract is close to the one from Susanne Stefer (Dötsch group, FFM) and our data complements each other. Thus, it would be great if our posters could be placed next to each other and if we could get the opportunity to present our studies.
Nature’s way to exploit hydrogen as alternative fuel
Invited Speaker
Other (free) Topics
Interaction of the lipid raft-associated protein flotillin-2 with membrane cholesterol
Poster
Membrane Biology, Chemical and Systems Biology
Characterization of a tRNA editing activity in Saccharomyces cerevisiae
Poster and application for short presentation
RNA Biology
Characterisation of type I metacaspases of the filamentous ascomycete Podospora anserina
Poster
Other (free) Topics
The myxobacterial compounds spirangien A and M522 are potent inhibitors of interleukin-8 expression
Poster and application for short presentation
Chemical and Systems Biology
Role of apoptosis-inducing factors in oxidative defense and assembly of respiration complexes
Poster
Other (free) Topics
Efficient linkage analysis of fluorescence labeled oligo- and polysialic acid by permethylation
Poster
Over-expression of the mitochondrial superoxide dismutase (PaSOD3) leads to alterations of lifespan, protein quality control and ROS scavenging system
Poster
Other (free) Topics
Folding mechanisms of a naturally evolved and two artificial (beta alpha) (8)-barrels: a comparative analysis
Poster and application for short presentation
Protein Structure and Dynamics
Role of flotillins in the trafficking and processing of the Alzheimer Amyloid Precursor Protein
Poster
Membrane Biology
Complex formation in DNA mismatch repair
Poster
Other (free) Topics
Intrinsic protein disorder and dynamics in regulation and signaling
Invited Speaker
Supranutritive selenium (Se) in combination with glucoraphanin (GRA) maximizes the expression of Nrf2-regulated genes in the colon of rats
Poster
Molecular Medicine
GPx2 is an unual selenoprotein, additionally regulated via Nrf2. Phase II enzymes are up-regulated by dietary isothiocyanates via Nrf2. We studied synergistic effects of selenium and glucoraphanin on GPx2 and phase II enzymes which are discussed in the context of prorection against colon cancer. Additional analyses on the protein concentrations or activity of the respective enzymes will be presented at the GBM-meeting.
Optimizing mouse brain preparation for microcomputed tomography analyses
Poster
Other (free) Topics
EU-OPENSCREEN – A European Infrastructure of Open Screening Platforms for Chemical Biology
Poster
Chemical and Systems Biology
Stabilization of Enzymes and Antibodies by Entrapment in Silica Biominerals
Poster and application for short presentation
Molecular Medicine, Protein Structure and Dynamics, Other (free) Topics
Entrapment of proteins with a biomimetic sol-gel approach confers protein stability.
Acetylation-Reporters for Residue-Specific Histone Deacetylase and Acetyl-Transferase Profiling in Real Time
Invited Speaker
Chemical and Systems Biology
N-terminal COFRADIC - a powerful method to analyze mitochondrial protein processing
Poster
Chemical and Systems Biology
Topology of the TRiC/CCT Chaperonin
Poster
Protein Structure and Dynamics
Age-related changes in abundance, posttranslational modification and supramolecular assembly of OxPhos enzymes in Podospora anserina
Poster
Membrane Biology
Characterization of Roco proteins
Poster
Protein Structure and Dynamics
Cooperative effect of cAMP and TGFβ in aggressive breast cancer
Poster and application for short presentation
Signaling – from Membranes to Nucleus
The molecular architecture of alphaB-crystallin reveals insights into its chaperone function and activation
Poster and application for short presentation
Protein Structure and Dynamics
This work on alpha-crystallin is based on the referenced publication from 2009. In the meantime, we have expanded our knowledge on the quaternary structure and its implications for the function of alpha-crystallin as molecular chaperone. These findings have been summarized in a further publication that has been currently submitted. Taken together, our data fill a critical, yet missing link between the static picture of alphaB-crystallin and its dynamics, and hence, provide mechanistic insight into its action.
Interleukin-1 interferes with the balance between proliferation and differentiation through insulin resistance in human keratinocytes – implications for psoriasis pathogenesis
Poster and application for short presentation
Molecular Medicine
Optimization and Comparation of Hidrophobic Interaction Chromatography, Strong Cation Exchange Chromatography and Capillary Isoelectric Focusing to Purify Anti-TNFα Fragments obtained After Papain Digestion
Poster
Other (free) Topics
Regulation of the proteasome in the ageing model Podospora anserina
Poster
Other (free) Topics
Lewis Blood Group Detection from Human Milk Oligosaccharide Mass Finger Prints
Poster and application for short presentation
Other (free) Topics
Donor specific Lewis blood group detection from isolated human milk oligosaccharides using matrix assisted laser desorption ionisation mass spectrometry.
Biological effects of copper complexes on human colon carcinoma and mouse embryonic fibroblast cell lines
Poster
Other (free) Topics
Cytotoxic and genotoxic effect of copper complexes on human colon carcinoma and mouse embryonic fibroblast cell lines.
Poster
Other (free) Topics
Microscale Analysis of Glycosphingolipids from Schistosoma mansoni Cercariae
Poster
Other (free) Topics
Microscale analysis of ceramide monohexoside and pentahexoside species from Schistosoma mansoni cercariae based on enzymatic digestion by sphingolipid ceramide N-deacylase in a two-phase liquid system.
Developing a novel zinc-finger nuclease with a sequence-specific cleavage module
Poster
Other (free) Topics
Enhanced Neuronal Ras Activation Influences the Adverse Phenotype in a Mouse Model of Rett Syndrome
Poster
Molecular Medicine, Signaling – from Membranes to Nucleus
Highly Specific Nucleases for Gene Therapy
Poster
Protein Structure and Dynamics
Stabilisation and activation of an artificial (beta alpha) (8)-barrel designed from identical (beta alpha) (4)-half-barrels
Poster and application for short presentation
Protein Structure and Dynamics
Searching for biogenesis factors of the NADH:ubiquinone oxidoreductase using the filamentous fungus Neurospora crassa
Poster
Membrane Biology
A graphical tool for visualization of functional modules in biochemical networks
Poster
Other (free) Topics
Fluorescence photoactivation as a tool to determine the dynamics of tau mRNA binding proteins
Poster
Other (free) Topics
Intragenic suppressor mutation helps bypassing the requirement for GTP hydrolysis by IF2 during translation initiation.
Poster and application for short presentation
Other (free) Topics
Oxidative protein folding in mitochondria
Invited Speaker
Other (free) Topics
Expression and characterization of an Aβ oligomer binding single-chain variable fragment – a novel tool for the treatment of Alzheimer’s disease?
Poster
Molecular Medicine, Other (free) Topics
A novel single-chain variable fragment for treatment of Alzheimer's disease.
Uncovering a temperature-depending role of the P. anserina i-AAA protease on lifespan
Poster
Other (free) Topics
Inclusion body formation in oligodendroglial cells after treatment with PR-619, an inhibitor of deubiquitination
Poster and application for short presentation
Protein Structure and Dynamics
Role of the amphiphilic helix of M2 for influenza virus budding
Poster and application for short presentation
Membrane Biology
Effects of extracellular alpha-synuclein on oligodendrocytes
Poster
Molecular Medicine
Cellular transfection with calcium phosphate/DNA nanoparticles – low intracellular calcium disturbance and further developments by PEI-functionalization
Poster and application for short presentation
Molecular Medicine
Combined use of Crystallography and CryoEM in the structure determination of giant hemocyanins
Poster and application for short presentation
Protein Structure and Dynamics
Hemocyanins are extremly large protein complexes with molecular masses of several MDa, which are of general interest as model systems for cooperative proteins and in cancer treatment. Structural analysis of hemocyanins is a challenge due to their size. We present recent advances in crystallographic analysis of hemocyanins.
PKC epsilon in Protein Translation
Poster
Other (free) Topics
Characterization of two conserved complexes of the archaeal CRISPR/Cas immune system
Poster
RNA Biology
Phosphoinositide-3-Kinase Vps34p is required for peroxisomal degradation in the yeast Saccharomyces cerevisiae
Poster
Other (free) Topics
Expression patterns of TRIM family members during Xenopus laevis organogenesis
Poster
Other (free) Topics
Export-driven Protein Import into Peroxisomes
Poster and application for short presentation
Other (free) Topics
New ligands of membrane-associated HIV-1 Nef
Poster
Molecular Medicine, Other (free) Topics
EGFR and HER2 expression and dimerization in esophageal cancer*
Poster and application for short presentation
Molecular Medicine
*Study supported by Deutsche Forschungsgemeinschaft DFG CRC850 project C5,and in part Mushett Family Foundation, Chester, NJ, US
TubStain, a novel non-antibody tool for direct labeling of microtubules
Poster
Other (free) Topics
N3BC – a powerful label for RNA, DNA and proteins alike
Poster
RNA Biology
Oxidative protein import into mitochondria of human cells
Poster
Other (free) Topics
Validation of metabolic networks in Arabidopsis thaliana
Poster
Other (free) Topics
Development and Optimization of a Conjugation Reaction for an efficient PEGylation of full human IgG1 (Anti TNFα) fragments
Poster
Other (free) Topics
Quantification of the HIV-1 Vif - ElonginC interaction by a new on bimolecular fluorescence complementation (BiFC) based assay
Poster
Molecular Medicine, Other (free) Topics
Molecular interactions of HDGF
Poster
Other (free) Topics
Imaging structure and function in the living brain
Invited Speaker
Other (free) Topics
A Methanococcus maripaludis endoribonuclease cleaves crRNA precursors
Poster
RNA Biology
The role of insulin signalling via the PI3-kinase/Akt/mTOR pathway and of the anti-apoptotic translationally controlled tumour protein TCTP in the development of drug resistance in colon cancer cells
Poster
Molecular Medicine
Increased insulin signalling in colon cancer cells results in activation of the PI3-kinase/Akt/mTOR pathway and increased expression of survival proteins, such as translationally controlled tumour protein TCTP.
Rhomboid proteolysis: why inside the membrane?
Invited Speaker
Membrane Biology
Identification of small molecule modulators of mitochondrial activity using functional assays with purified biological active mitochondria
Poster
Other (free) Topics
Presequence binding to Tim50 studied by photocrosslinking
Poster
Protein Structure and Dynamics
The glutathione redox milieu of the IMS is controlled by the cytosol
Poster
Other (free) Topics
Cooperation of ADP-ribosylation factor 1 (Arf1) and Coatomer in membrane scission
Poster
Membrane Biology
Cav2.3- and Cav3.2-deficient mice both display seizure resistance in the kainic acid model of epilepsy
Poster
Molecular Medicine, Protein Structure and Dynamics, Signaling – from Membranes to Nucleus
Towards a high throughput screening of inhibitors for Streptococcus pneumoniae
Poster
Other (free) Topics
Cyclolisation: The last step in the biosynthesis of D-lysergic acid alkaloids
Poster
Chemical and Systems Biology
Covalent protein modification with ISG15 via a conserved cysteine in the hinge region
Poster
Protein Structure and Dynamics, Chemical and Systems Biology, Other (free) Topics
Molecular evolution of SRP-GTPase activation by protein
Poster and application for short presentation
Protein Structure and Dynamics
We present the structure of the SRP-GTPase FlhF in complex with its newly identified activator. This study defines the mechanism of SRP-GTPase activation.
Domain studies on Remorin AtREM1.3 intrinsic disorder
Poster
Protein Structure and Dynamics, Signaling – from Membranes to Nucleus
Covalently Trapping of MutS on DNA
Poster
Protein Structure and Dynamics
Novel Selective Inhibitors of Cyclin Dependent Kinase 7
Poster and application for short presentation
Other (free) Topics
We generated picomolar an monoselective inhibitors of CDK7, which we used to validate CDK7 as a cancer target in vitro and in vivo, as well as to examine the role of CDK7 in other biological processes in various cell types.
Analyzing microtubule dynamics in living cells using fluorescence photoactivation
Poster
Protein Structure and Dynamics
Influence of alternative splicing events to secondary structure of proteins
Poster
Protein Structure and Dynamics
Effects of Redox Imbalances on the Mitochondrial Disulfide Proteome
Poster
Protein Structure and Dynamics
Detergent-resistant membranes are essential along the signalling pathways of prostate-specific membrane antigen
Poster
Signaling – from Membranes to Nucleus
Structure and Biochemical Studies on Sept7
Poster and application for short presentation
Protein Structure and Dynamics
PAPS synthases - naturally fragile enzymes specifically stabilised by nucleotide binding
Poster and application for short presentation
Molecular Medicine, Protein Structure and Dynamics, Signaling – from Membranes to Nucleus
One is enough: functional stoichiometry of tapasin for MHC I antigen presentation
Poster and application for short presentation
Membrane Biology
Development of a highly specific DNA nicking nuclease
Poster
Other (free) Topics
Coa3 and Cox14 are essential for cytochrome c oxidase assembly and negative feedback regulation of COX1 translation in mitochondria
Poster and application for short presentation
Membrane Biology
Small but important – various functions of the N-terminal domain TMD0
Poster
Membrane Biology
Function of PP2A-dependent signalling in early neurogenesis of vertebrates.
Poster
Molecular Medicine
FSA-Catalyzed Carboligation: New Synthetic Opportunities from an Ancient Enzyme Scaffold
Poster
Protein Structure and Dynamics
In vitro reconstitution of both steps of splicing and investigation of the spliceosome dynamics
Poster and application for short presentation
Protein Structure and Dynamics, RNA Biology
Epsin N-terminal homology domains bind on opposite sides of two SNAREs
Poster
Other (free) Topics
Rab32 directly interacts with LRRK2 and mediates its transport to and from the pericentriolar endosome
Poster
Other (free) Topics
Atp23 – An unconventional substrate of the Mia40 import pathway
Poster
Protein Structure and Dynamics
Uptake of various yeast genera by antigen-presenting cells and influence of subcellular antigen localization on the activation of ovalbumin-specific CD8 T lymphocytes
Poster and application for short presentation
Molecular Medicine, Other (free) Topics
The small GTPase Rab6 interacts with Mint1
Poster
Other (free) Topics
Mrp10 – A Regulator of Mitochondrial Protein Synthesis?
Protein Structure and Dynamics
Identification and detailed characterization of novel regulators of cellular cholesterol metabolism
Poster and application for short presentation
Signaling – from Membranes to Nucleus
MODULATION OF alpha-TOXIN BINDING BY MEMBRANE COMPOSITION
Poster and application for short presentation
Membrane Biology
Highly efficient and more general cis- and trans-splicing inteins through sequential directed evolution
Poster and application for short presentation
Chemical and Systems Biology
Studies on the chemical structure requirements of a semisynthetic split intein
Poster and application for short presentation
Chemical and Systems Biology
Bacterial production and functional characterization of the satiety hormone leptin as a potential therapeutic agent with prolonged plasma half-life
Poster
Protein Structure and Dynamics
Laboratory reconstruction of the evolution of a bi-substrate specific sugar isomerase
Poster and application for short presentation
Protein Structure and Dynamics
Generating highly specific nucleases by a fusion approach
Poster and application for short presentation
Other (free) Topics
Whole Yeast Delivering Recombinant Virus-Like Particles Stimulates Antigen-Specific Memory CD4+ and CD8+ T Cells
Poster
Other (free) Topics
Development and characterization of an exendin-4 variant with extended plasma half-life by PASylation®
Poster
Protein Structure and Dynamics
Trimannosyl structure on stem cells and carcinomas/inflamed tissue recognized by Mannitou antibody
Poster and application for short presentation
Other (free) Topics
Characterization of GET Protein Distribution in S.cerevisiae Under Different Physiological Conditions – From Light Microscopy to Ultrastructural Analysis
Poster and application for short presentation
Membrane Biology
High-throughput analysis of kinetic ELISA-microarray data
Poster and application for short presentation
Signaling – from Membranes to Nucleus, Chemical and Systems Biology
Different substrate-dependent transition states in the active site of the ribosome
Poster and application for short presentation
RNA Biology
The characterization and analysis of Pap10 in mitochondria
Poster
Membrane Biology
Quantitative analysis of ADP receptor activation of human platelets
Poster and application for short presentation
Signaling – from Membranes to Nucleus
Global phosphorylation analysis of ADP/Prostaglandine stimulated platelets via iTRAQ and subsequent targeted SRM approaches for regulated peptides.
Influence of RAGE and aging on CREB and cAMP/CREB-regulated genes in lung tissue
Poster
Signaling – from Membranes to Nucleus
Recent advances in the mechanism of the SRP GTPase regulation
Poster
Protein Structure and Dynamics
Investigation of tRNA Modifications and their structural impact
Poster
RNA Biology
The Da Vinci Code of TAP - Decoding the conformation of antigenic peptides bound to TAP by EPR spectroscopy
Poster and application for short presentation
Membrane Biology, Protein Structure and Dynamics
The unique complexity and responsiveness of the regulatory redox network in plant cells
Invited Speaker
Chemical and Systems Biology
Karl-Josef Dietz Biochemistry and Physiology of Plants W5-134, Bielefeld University, 33501 Bielefeld, Germany. E-mail: karl-josef.dietz@uni-bielefeld.de
Labeling of proteins using a naturally split intein
Poster
Chemical and Systems Biology
Impact of RNA modifications on TLR7 recognition
Poster
RNA Biology
Investigating the dynamics of tRNA protein complexes by single molecule fluorescence spectra
Poster
RNA Biology
HAMP-membrane interactions correlate with the signaling mechanism and subcellular localization of HAMP-containing receptors
Poster and application for short presentation
Signaling – from Membranes to Nucleus
HAMP domains are found in more than 5000 membrane-spanning prokaryotic receptors. This is the first study that demonstrates their ability to interact with membranes. The propensity for HAMP-membrane interactions correlates with the signaling mechanism and subcellular localization of HAMP-containing receptors. This is important for anyone studying prokaryotic signal transduction.
Interference of the Epstein-Barr viral protein BNLF2a with the intracellular antigen transporter machinery TAP
Poster
Membrane Biology
Analysis of the sliding process of restriction enzymes by single molecule techniques
Poster
Other (free) Topics
Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
Poster
Molecular Medicine, Other (free) Topics
Nrf2 protects hepatocytes against oxidative liver injury and has a role in liver regeneration via stem cell activation.
Poster
Molecular Medicine, Other (free) Topics
Reversible activation of a transcription factor by methionine oxidation
Poster and application for short presentation
Other (free) Topics
redox biology Identification of a novel transcription factor that is reversibly activated upon hypochlorite stress and specifically protects cells from hypochlorite-induced killing.
Regulation of Proteasome Homeostasis
Poster
Other (free) Topics
intracellular proteolysis quality control nucleotransport
Glycoproteomic analysis – opportunities and threats
Invited Speaker
Other (free) Topics
Glycoproteomics is required for the large scale analysis of glycosylation sites in complex cellular systems. The presented workflows enable the detection of hundreds of glycosylation sites in parallel and have a prospect for in depth analysis of glycosylations in the future.
The PKB/Akt substrate AS160 facilitates opioid-induced neurite outgrowth and cell differentiation
Poster and application for short presentation
Signaling – from Membranes to Nucleus
Profiling cellular signaling of G-protein coupled receptors
Poster
Signaling – from Membranes to Nucleus
Rotors of ATP synthases
Poster and application for short presentation
Membrane Biology
Molecular analysis of increased cognitive performance in Sharp1 and Sharp2 double knockout mice
Poster
Molecular Medicine
Screening of a naïve VHH antibody library from non-immunized Lama glama using phage and yeast display and isolation of binders against various targets
Poster and application for short presentation
Molecular Medicine
Inclusion body display: in vivo protein immobilization for applications in biochemistry and biotechnology
Poster and application for short presentation
Other (free) Topics
TNF-α induced Nrf2 activation in monocytes
Poster and application for short presentation
Signaling – from Membranes to Nucleus
RNA-guided immunity: a novel RNA maturation pathway for the production of CRISPR RNAs targeting genome invaders
Invited Speaker
RNA Biology, Other (free) Topics
In bacteria and archaea, CRISPR (clustered, regularly interspaced short palindromic repeats)/Cas (CRISPR-associated proteins) constitutes an adaptive RNA-based defence system against invading alien genomes (phages or plasmids) wherein short spacer/repeat-derived CRISPR RNAs (crRNAs) silence foreign nucleic acids in a sequence-specific manner. The maturation of crRNAs represents a key event in CRISPR activation. Here, the molecular mechanisms involved will be discussed with a focus on the so-called CRISPR/Cas system II.
Producing more oil in plants
Invited Speaker
Other (free) Topics
Structural Basis for Redox-Linked Proton Translocation by Mitochondrial Complex I
Poster and application for short presentation
Protein Structure and Dynamics
X-ray crystallographic analysis of mitochondrial complex I
Crystal Structure of D-Serine Dehydratase from Escherichia coli
Poster
Protein Structure and Dynamics
Crystal structure of D-serine dehydratase from Escherichia coli is described and a putative catalytic reaction mechanism proposed.
A new type of heme-copper oxidase with alternative electron donors regulated by cytochrome bc1 complex in its supercomplex system
Poster and application for short presentation
Membrane Biology
Key cytokines in the pathogenesis of psoriasis induce insulin resistance at the endothelial cell level
Poster and application for short presentation
Molecular Medicine
A novel fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins
Poster and application for short presentation
Molecular Medicine
New disease linked to lipoic acid synthase maturation as an FeS protein
Phosphorylation of TRPV1 explains only small portion of heterogeneous Capsaicin Responses in Dorsal Root Ganglia Neurons
Other (free) Topics
Kinase mediated sensitization of the ion channel TRPV1 plays only a minor role in the capsaicin response heterogeneity of primary sensory neurons.
Developing novel methods for systems biology of membrane protein complexes
Poster
Chemical and Systems Biology
Adipogenesis is promoted by an elevated adiponectin level
Poster
Molecular Medicine
The local anesthetic phenylethanol modulates transmembrane protein folding
Poster and application for short presentation
Membrane Biology, Protein Structure and Dynamics
Anesthetics affect's TM protein structure
Cell-Free Production of Human Solute Carriers
Poster
Membrane Biology
Automated high-throughput crystallization suited for membrane proteins at the ESFRI Instruct Core Centre Frankfurt
Poster
Protein Structure and Dynamics
Potent inhibitors of a type II transmembrane serine protease
Poster
Protein Structure and Dynamics
tructure and dynamics of the immuno-active GTPase hGBP1 studied by single molecule FRET and DEER EPR
Poster and application for short presentation
Protein Structure and Dynamics
Antagonist recognition of a G protein-coupled receptor
Poster and application for short presentation
Protein Structure and Dynamics
Cytochrome P450 systems that oxidise carrier protein bound substrates: molecular recognition and specificity in small molecule oxidation
Poster and application for short presentation
Other (free) Topics
Structural and functional insights into a novel class of cryptochromes, the CryPro family.
Poster and application for short presentation
Protein Structure and Dynamics
Ready, steady, go - viral polymerase at work!
Poster and application for short presentation
Protein Structure and Dynamics, RNA Biology
Characterization of two isoforms of cbb3 cytochrome oxidase from Pseudomonas stutzeri ZoBell
Poster
Membrane Biology
Directing Cell-free Expressed Membrane Proteins into Lipid Bilayers: Evaluating the L-CF Mode and the Nanodisc Technology
Poster and application for short presentation
Membrane Biology
Pathological biochemical pathways cured by homeopathic potencies identified as photons.
Poster and application for short presentation
Molecular Medicine
Detection of photons in homeopathic potencies cure pathological biochemical pathways according to the physical principle of resonance. Chronic diseases, Hashimoto thyreoditis, asthma, paralyses are cured by applying highly potentized substrates and inhibitors of the concerned pathways to the patients
The killer within: inhibition of cell wall synthesis by ζ toxins.
Poster and application for short presentation
Other (free) Topics
Structural insights into a class II photolyase: A new theme of light-driven DNA repair
Poster and application for short presentation
Protein Structure and Dynamics
Ion-Channel Engineering with mVDAC1 and OmpG
Poster and application for short presentation
Protein Structure and Dynamics
Understanding the binding mode and function of glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum with TLR2 complexes
Poster
Protein Structure and Dynamics
Biogenesis of the mitochondrial ABC-transporter Mdl1 involves mitochondrial import and export machineries
Poster
Membrane Biology
Analysis of Traf3 alternative splicing during T cell activation
Poster
RNA Biology
In our work we present evidence that Traf3 is alternatively spliced during T cell activation. We have started to investigate the underlying mechanism and show that this splicing switch regulates NFkB activation.
Targeted disruption of BRAF V600E in colorectal cancer as a model system for the identification of novel approaches towards individualized tumor therapy
Poster and application for short presentation
Molecular Medicine
Genetic interference with Taspase1 heterodimerization will not aid to target t(4;11) leukemias
Poster and application for short presentation
Molecular Medicine, Protein Structure and Dynamics
Probing Taspase1 multimerization in vivo
Computational Molecular Design - Shaping Protein Conformations and Predicting Functional Sequences
Invited Speaker
Protein Structure and Dynamics
Differentiation and stemness maintenance of neural stem cells
Invited Speaker
Signaling – from Membranes to Nucleus
Genomic traces of the coevolution of archaea and viruses
Invited Speaker
RNA Biology
Prokaryotic antiviral defense mediated by CRISPR/Cas type I-E
Invited Speaker
RNA Biology
“Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in the amelioration of amyotrophic lateral sclerosis (ALS)”
Poster
Other (free) Topics
Molecular mechanism of betaine transport and stress regulation by the Na+-coupled symporter BetP
Invited Speaker
Other (free) Topics
Structure and function of P-type ATPase cation pumps
Invited Speaker
Membrane Biology, Protein Structure and Dynamics
Crystal structures of P-type ATPases compared to biochemical and biophysical studies reveal their transport mechanisms and their role in cell biology and physiology
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting the E3-ligase β-TrCP1
Poster and application for short presentation
Molecular Medicine
Throughput applications of cell-free expression systems
Poster
Other (free) Topics
Helix bundle structure of the sodium/proline symporter PutP obtained by DEER distance measurements in a native lipid environment.
Poster and application for short presentation
Protein Structure and Dynamics
Early phases of protein aggregation probed in vivo
Invited Speaker
Other (free) Topics
Cell-Free Expression of GPCRs
Poster
Other (free) Topics
Systematic high-speed imaging of organogenesis in entire zebrafish
Invited Speaker
Other (free) Topics
A quantitative view of gene expression levels in T helper cells
Invited Speaker
Other (free) Topics
It is of fundamental importance to understand the global distribution of gene expression levels in cells, and to be able to interpret it mechanistically and functionally. Here we use RNA sequencing (RNA-seq) of mouse Th2 cells, coupled with a range of other techniques, to show that all genes can be separated, based on their expression abundance, into two distinct groups.
New Lessons in Regulation of the EGFR/ErbB Family of Receptor Tyrosine Kinases
Invited Speaker
Signaling – from Membranes to Nucleus
In Vivo imaging of Alzheimer`s disease mouse models
Invited Speaker
Other (free) Topics
Targeting Polo-like kinase 1 provides a new approach to enhance chemosensitivity of rhabdomyosarcoma
Poster
Molecular Medicine
A unique ceramide synthase is absolutely required for skin barrier functions
Poster and application for short presentation
Other (free) Topics
Epidermis-unique ceramides and their essential role in skin barrier function have been the focus of our latest investigations. By means of in vitro studies with living human and yeast cells, as well as with the in vivo depletion of the newly identified ceramide synthase absolutely required for skin barrier functions will be presented. Our studies will provide new insights into the functional role of epidermal sphingolipids in keratinocyte differentiation.
Structural studies of hGBP1 helical domain (alpha7-alpha13)
Poster
Protein Structure and Dynamics
REGULATION OF THE ACTIVITY OF TAp63α IN OOCYTES BY ITS OLIGOMERIC STATE
Poster and application for short presentation
Other (free) Topics
-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution
Poster and application for short presentation
Membrane Biology
First fully functional bacterial complex III was crystallized and the X-ray structure determined at 2.7-Å resolution. Truncation of the organism-specific, acidic N-terminus of cytochrome c1 changes the oligomerization state of the enzyme to a dimer. Compairison of complex III structures even confirm the hypothesis of cyt b/ISP as the evolutionary core and reveals structural differences in cytochrome c1 We suggest a model for the electron transfer complex with the native substrate cytochrome c552 of the complex.
From pockets to ligands and back again: Designing bioactive compounds
Invited Speaker
Chemical and Systems Biology
Characterization of the DnaK Chaperone Network in the Cyanobacterium Synechocystis sp. PCC 6803
Poster
Other (free) Topics
Structural studies of the maltose transporter
Invited Speaker
Membrane Biology
The Continued Evolution of the Genetic Code
Invited Speaker
RNA Biology
High content/throughput microscopy identifies novel networks in membrane traffic and organelle biogenesis
Invited Speaker
Other (free) Topics
Microscopy based genome-wide siRNA screens in fixed and living cells reveal metabolic and signaling pathways regulating membrante traffic of the early secretory pathway and Golgi biogenesis/maintenance
Genome-wide siRNA screening reveals XIAP as essential factor for NOD1-mediated innate immune signalling
Poster and application for short presentation
Signaling – from Membranes to Nucleus
New insights into NOD1 innate immune signalling.
Surviving in the absence of air – analysis of the anaerobic hydrogen metabolism of the microalga Chlamydomonas by RNA-Seq and classical approaches
Invited Speaker
Other (free) Topics
Structural and functional analysis of the cyanobacterial phytochrome Cph2 from Synechocystis sp.
Poster and application for short presentation
Protein Structure and Dynamics
Hydrogen peroxide decomposition by aa3 cytochrome c oxidase from Paracoccus denitrificans
Poster
Membrane Biology
Assembly and Stability of the Transmembrane Cytochrome b6
Poster
Membrane Biology
The P intermediates of cytochrome c oxidase from Paracoccus denitrificans
Poster
Other (free) Topics
Proton Transfer and Reactive Oxygen Species in the Cytochrome bc1 Complex
Poster
Membrane Biology
MST1 and Nore1 interactions in apoptotic signalling
Poster
Signaling – from Membranes to Nucleus
Kinetic and calorimetric characterisation of Nore1/MST1 interactions in order to define the thermodynamic equilibria of the homo- and heterodimer complexes.
EPR on type I and type II ABC importers
Poster and application for short presentation
Protein Structure and Dynamics
We use electron paramagnetic resonance to study (i) the maltose-dependent interaction between MalE and the type I maltose importer, and (ii) the opening and closing of the translocation gates in the type II vitamin B12 importer.
Specific Interactions Mediate Oligomerization and Function of the E. coli Glycerol Facilitator GlpF
Poster
Protein Structure and Dynamics
Investigating the Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) in rat hippocampal neurons
Poster
Other (free) Topics
Effective Excited State Deactivation of Flavins in Archeal Dodecin Proteins
Poster
Protein Structure and Dynamics
Transient UV/vis spectra of dodecin proteins from Halobacterium salinarum were taken to investigate the mechanism of the excited state quenching of protein bound flavins.
Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP
Poster and application for short presentation
Signaling – from Membranes to Nucleus
The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High Resolution Imaging
Poster and application for short presentation
Other (free) Topics
Deep sequencing and high resolution imaging reveals the local transcriptome in the hippocampal synaptic neuropil
Poster and application for short presentation
RNA Biology
phage display identification of peptides that bind Parvlin 14/17
Poster and application for short presentation
Identification of the host cell receptor of Clostridium difficile toxin CDT
Poster and application for short presentation
Molecular Medicine, Membrane Biology, Other (free) Topics
The binary actin-ADP-ribosylating toxin CDT is produced by endemic hypervirulent strains of the human enteric pathogen Clostridium difficile. A haploid genetic screen identifies the host cell receptor for binding and uptake of CDT into target cells.
Binding Characteristics of epithelial adhesins from Candida glabrata
Poster
Protein Structure and Dynamics
The structure and binding characteristics of Epa family members were investigated.
RNA aptamers specific for the Interleukin-6 receptor
Poster
RNA Biology
Structural basis of flocculin-mediated adhesion in yeast
Poster and application for short presentation
Protein Structure and Dynamics
Here we report the structure of Flo5A, an adhesin of the PA14 family, showing for the first time an important substructure for calcium binding. Furthermore an astonishing, seven-membered gadolinium cluster on the protein's surface is discussed.
Microarray analysis of NGF/TrkA-induced genes in the human mast cell leukemia cell line HMC-1 identifies novel TrkA target genes which support survival and/or proliferation
Poster and application for short presentation
Signaling – from Membranes to Nucleus
Novel NGF/TrkA target genes which are involved in survival/proliferation of leukemia cells
Molecular interactions and function of the HOPS complex
Poster and application for short presentation
Membrane Biology
Probing the signalling complexity of tumor cells by functional screening of peptide and small molecule libraries
Poster and application for short presentation
Chemical and Systems Biology
Peptide and small molecule libraries can be used to screen for complex receptor activity patterns in cancer cells, yielding new drug target candidates.
Translational Enhancement via mRNA Binding to Scp160p in Yeast - Assessed by Bioinformatics and Ribosome-Affinity Purification (RAP)
Poster
RNA Biology
High-affinity antibodies against functional recombinant NhaA from Salmonella typhimurium generated with an avian immune phage-display library
Poster
Membrane Biology
Sensitizing neuroblastoma for TRAIL-induced apoptosis by Bortezomib
Poster
Other (free) Topics
Epigenetic mechanisms of PADI4 in hematopoiesis and evaluation as a therapeutic target
Poster
Signaling – from Membranes to Nucleus
Identification and characterisation of transcriptional coregulators
Macromolecular reorganizations in mitochondria during aging
Poster and application for short presentation
Membrane Biology
Assembly of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1
Poster
Membrane Biology, Protein Structure and Dynamics
An atypical link between Wrch1/RhoU and multiple upstream signals is mediated through only one of its N-terminal SH3-domain binding motifs
Poster
Chemical and Systems Biology
Mechanistic Insights into Specificity, Activity and Regulatory Elements of the RGS-containing Rho-specific Guanine Nucleotide Exchange Factors p115, PDZ-RhoGEF (PRG) and Leukemia- associated RhoGEF (LARG)
Poster
Chemical and Systems Biology
25 years of Ras structural biochemistry: interaction and network perspectives
Poster
Signaling – from Membranes to Nucleus
New insights into the interaction between the semaphoring receptor plexin B1 and the small GTPases of the Rho family
Poster
Chemical and Systems Biology
Catalytic regulation of RING between RING (RBR) finger protein HOIP
Poster
Signaling – from Membranes to Nucleus
Designer Enzymes
Invited Speaker
Characterization of the interaction between an ACP domain and a halogenase in the curacin A polyketide synthetase
Poster
Protein Structure and Dynamics
Deciphering the platelet tyrosine phosphoproteome by SH2-domain profiling
Poster and application for short presentation
Signaling – from Membranes to Nucleus
A V-type c subunit in an archaeal ATP synthase: Probing the Na+ binding site in the rotor
Poster
Membrane Biology
NMR structure of the seven transmembrane helix protein proteorhodopsin
Poster
Protein Structure and Dynamics
Choline and glycine betaine transport in A. baylyi
Poster
Membrane Biology
Mechanism of CuA Assembly in the Biogenesis of Cytochrome c Oxidase
Poster
Membrane Biology
Understanding Lung Cancer
Poster and application for short presentation
Molecular Medicine
Overcoming Gatekeeper Mutations in Kinases by Hybrid Compound Design
Poster
Chemical and Systems Biology
Structural and Functional Analysis of the Archaeal Endonuclease Nob1
Poster
RNA Biology
Development of tetracycline inducible self-cleaving RNA switches
Poster
RNA Biology
Compartmentalized Vacuolar-ATPase-regulated Intracellular Prostate-Specific Antigen (VIP) in Prostate Cancer Cells: Novel findings on the Regulation of the Biomarker
Poster and application for short presentation
Molecular Medicine
We discovered a novel axis in the regulation of prostate-specific antigen expression, storage, and secretion by vacuolar ATPases.
Microbial Rhodopsins: Light-gated ion channels and pumps as optogenetic tools in neuro- and cell biology
Invited Speaker
Investigation of the POTRA Domains from Cyanobacterial Omp85 by PELDOR Spectroscopy
Poster
Protein Structure and Dynamics
Control of plant Hsf function and stability by Hsp70/Hsp90 chaperones and the cochaperones Chip and Hop
Poster
Other (free) Topics
The Evolutionary Flip of Chloroplast Omp85 Proteins
Poster
Membrane Biology
Spatiotemporal control of Ras plasma membrane interactions
Invited Speaker
RNA-based control of wiring the brain
Invited Speaker
Ras chaperons for cancer therapy and Ras transfer from cell-to-cell
Invited Speaker
Molecular aspects of light to biomass to fuel conversion with microalgae
Invited Speaker
Assembling the buidling blocks of motor behavior: from peripheral axon signaling to motor unit plasticity
Invited Speaker
A two dimensional ERK-AKT signaling map encodes a cell fate decision
Invited Speaker
Development of Antibiotic RNA Aptamers
Poster
RNA Biology
A Blueprint for Cellulose Synthesis in Higher Plants
Invited Speaker
CBS domains 1 and 2 fulfill different roles in ionic strength-sensing of the ABC transporter OpuA
Invited Speaker
Tools for reconstituting intracellular signaling networks
Invited Speaker
PKA: Assembly of Dynamic Macromolecular Signaling Scaffolds
Invited Speaker
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