Dnmt2: Expression profile of a cell-cycle gene?

The highly conserved methyltransferase Dnmt2, which contains motifs of a classical DNA (cytosine-5)-methyltransferases, appears to play a dual-specific role showing DNA m5 methyltransferase and RNA methyltransferase activity.
Here we provide insights into the expression profile of the Dictyostelium discoideum homolog DnmA.
By quantitative analysis we show that DnmA, which displays in general very low expression levels, is developmentally regulated in Dictyostelium.
It is intriguing to note that DnmA shows a peak of expression at approx. 16 hours in the developmental cycle. At this time, a substantial fraction of the cells in an aggregate appear to go through a cell division cycle. Comparison with other genes involved in cell cycle regulation shows that many of them show a similar expression profile. The assumption that DnmA plays a role in mitosis or DNA replication is supported by the observation that localisation of the protein changes during the cell cycle.
In contrast to other organisms (e.g. Drosophila), we found that DnmA is not localized to cytoplasmic (stress) granula after stress treatment; instead the localization remains stable in the nucleus.