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List of Abstracts

Modulating Transcription in human cells using small RNAs
Invited Speaker
RNA-mediated regulation in transcription: emerging principles
RNAi is generally associated with recognition of mRNA and post-transcriptional inhibition of gene expression. We have observed that small RNAs can also recognize noncoding transcripts and activate or inhibit gene transcription.
RNA-based transcription regulation
Invited Speaker
RNA-mediated regulation in transcription: emerging principles
Role of RNase J in the regulation of RNA stability in the gastric pathogen Helicobacter pylori
Poster
RNA regulatory networks in prokaryotes
Chitosan/siRNA nanoparticles for biological refinement of medical implants
Poster
other (free) topics
Small RNA-Based Prokaryotic Immunity via the CRISPR-Cas system
Invited Speaker
Hot topics in regulation
Identification and Characterization of small RNAs in Agrobacterium tumefaciens
Poster
RNA regulatory networks in prokaryotes
Small RNAs in Agrobacterium tumefaciens
Regulatory RNA in cyanobacteria: Developmental decisions, stress responses and a plethora of chromosomally encoded cis-antisense RNAs
Invited Speaker
RNA regulatory networks in prokaryotes
Influence of Different Stress Conditions on the Subcellular Distribution of ALG-2, RBM22 and hSlu7
Poster
other (free) topics
A pH responsive RNA regulator
Invited Speaker
Regulation via ligand-induced conformational changes
Identification of the RNA dependent RNA polymerase and mechanism of chromatin maintenance
Invited Speaker
Hot topics in regulation
Qbetter SELEX: putting the Spiegelman monsters behind bars
Poster
other (free) topics
In vitro repair of a deletion mutation within a model substrate of the oncogenic CTNNB1 mRNA
Poster
other (free) topics
Chromatin interacting RNA maintains accessible higher order structures of chromatin
Poster
RNA-mediated regulation in transcription: emerging principles
Diversity of structural responses of riboswitches to cognate ligand binding
Invited Speaker
Regulation via ligand-induced conformational changes
Natural and artificial riboswitches exhibit idiosyncratic structural responses to ligand binding.
The Chemical Biology of Large-Scale Transcriptome Analysis
Invited Speaker
RNA-mediated regulation in transcription: emerging principles
Mechanisms for processing small RNAs in C. elegans
Invited Speaker
Mechanisms of micro-RNA function
Posttranscriptonal regulation of the microRNA-17-92 cluster
Poster
Mechanisms of micro-RNA function
7SK RNA/HMGA1 complexes in gene expression regulation.
Poster
RNA-mediated regulation in transcription: emerging principles
The small nuclear 7SK RNA negatively controls transcription by inactivating positive transcription elongation factor b (P-TEFb). We show that 7SK RNA also directly controls the activity of the transcription regulator HMGA1.
Dnmt2: A multi-substrate RNA methyltransferase?
Poster
other (free) topics
Mechanisms of miRNA-mediated gene silencing
Invited Speaker
Mechanisms of micro-RNA function
Posttranslational modifications of the HP1-homologes HcpA and HcpB in Dictyostelium discoideum: functional role of a highly conserved Lysin in the chromo-shadow domain.
Poster
other (free) topics
What makes a 5’UTR an RNA thermometer?
Poster
RNA regulatory networks in prokaryotes
RNA thermometers are 5'-UTRs which regulate translation via temperature-induced structural alteration.
Uncovering layers of human RNA polymerase II transcription
Invited Speaker
RNA-mediated regulation in transcription: emerging principles
Beyond microRNAs: treasures in short-read sequencing data
Invited Speaker
Hot topics in regulation
Different Folding Kinetics of Two Homologous Riboswitch Aptamer Domains.
Poster
Regulation via ligand-induced conformational changes
Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC
Poster
other (free) topics
The CRISPR-Cas system from Haloferax volcanii
Poster
Hot topics in regulation
Small RNA guided invader defense
Invited Speaker
RNA regulatory networks in prokaryotes, other (free) topics
Bacterial RNA thermometers – Molecular zippers or switches?
Invited Speaker
Regulation via ligand-induced conformational changes
Investigation of aberrant vs. normal translation termination in HeLa extracts
Poster
other (free) topics
In vitro Selection of a hairpinribozyme for cleavage and ligation of substrates beyond the consensus sequence
Poster
other (free) topics
The proto-oncogene Pim-1 is a target of miR-33a
Poster
Mechanisms of micro-RNA function
We found a regulation of the oncogenic kinase Pim-1 by miR-33a. The miR-33a dependent downregulation of Pim-1 results in decelerated cell proliferation and cell cycle progression.
MicroRNA-31 is cell cycle-regulated
Poster
Hot topics in regulation
A hidden layer of genetic information - regulatory ncRNAs in a model cyanobacterium
Poster
RNA regulatory networks in prokaryotes
Interdependence of asRNAs and RNase E on gene regulation during phage infection in Prochlorococcus
Poster
RNA-mediated regulation in transcription: emerging principles
The global regulator Hfq participates in the singlet oxygen stress response of Rhodobacter sphaeroides
Poster
RNA regulatory networks in prokaryotes
Molecular Characterization of two argonaute-like proteins in D. discoideum
Poster
RNA-mediated regulation in transcription: emerging principles
Dnmt2: Expression profile of a cell-cycle gene?
Poster
other (free) topics
Defining a function for the archaeal CPSF protein
Poster
Hot topics in regulation
Novel toxin-antitoxin systems in cyanobacteria
Poster
other (free) topics
Analysis of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) systems in the cyanobacterium Synechocystis sp. PCC 6803
Poster
Hot topics in regulation
IN VITRO SELECTION OF APTAMERS WITH ANTIBACTERIAL POTENTIAL
Poster
other (free) topics
Gain of function in a tRNA nucleotidyltransferase deletion variant
Poster
other (free) topics
Yfr20 – the first light sensing non-coding RNA in Prochlorococcus marinus
Poster
other (free) topics
SyR22, a new player in the iron-regulatory network of Synechocystis PCC6803
Poster
RNA regulatory networks in prokaryotes
Characterization of a tRNA editing activity in Saccharomyces cerevisiae
Poster
other (free) topics
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Poster
other (free) topics
Freiburg RNA Tools: a web server for the computational analysis of non-coding RNAs
Poster
other (free) topics
Posttranscriptional gene regulation under hypoxia
Poster
Hot topics in regulation
A porcine microRNA and its targets
Poster
other (free) topics
Revising RNA Amplification - Improved on-bead amplification of scarce, unknown RNA species
Poster
other (free) topics
Characterization of novel microRNAs associated with differentiation of human embryonic stem cell-derived neural stem cells
Poster
other (free) topics
Biochemical and pre-steady-state kinetic characterization of recombinant human Argonaute2
Poster
Mechanisms of micro-RNA function
Structural insights into cis element recognition of non-polyadenylated RNAs by the Nab3-RRM
Poster
RNA-mediated regulation in transcription: emerging principles
Analysis of 6S RNA-derived short pRNAs from Bacillus subtilis
Poster
RNA-mediated regulation in transcription: emerging principles
CRISPR revisited: structure prediction of CRISPR repeats
Poster
Hot topics in regulation
Development of a microfluidic approach and its application to
Poster
Regulation via ligand-induced conformational changes
Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum
Poster
Hot topics in regulation
Presentation of data on the organisation and activity the Y.pestis type CRISPR/Cas system in P.atrosepticum and on the processing of the CRISPR RNA
Structure of CRISPR associated protein Csn2 from Streptococcus agalactiae
Poster
Hot topics in regulation
Zinc Finger Nuclease-mediated silencing of non-protein-coding RNA
Poster
other (free) topics
The presented method allows fast and simple creation of loss-of-function cell lines for non-coding RNAs or any other gene. It is based on the ZFN-mediated site-specific integration of RNA destabilizing elements into the genome.
Crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1
Poster
other (free) topics
The crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1 yields insights into evolution and function of the eukaryotic ribosome in translation initiation.
Analysis of disease-correlated SNPs in microRNA targets reveals a potential role of RNA structure for microRNA function
Poster
Mechanisms of micro-RNA function
An aptamer targeting the apical-loop domain modulates pri-miRNA processing
Poster
Mechanisms of micro-RNA function
A regulatory circuit based on AS-NMD of RNA-binding proteins mediates biological timing
Poster
Hot topics in regulation
For the first time, the Nonsense mediated decay pathway coupled to alternative splicing has been implicated in the circadian clock meachanism.
The impact of bifunctional microRNA-9/9* on the differentiation of human ES cell - derived neural stem cells
Poster
other (free) topics
Analysis of short non-coding RNA–DNA-protein interaction networks in Pyrococcus furiosus
Poster
other (free) topics
Novel metabolite analogues for modulating riboswitch activity
Poster
Regulation via ligand-induced conformational changes
Characterization of Butyrate response factor-2 (BRF2) in AU-rich element-mediated mRNA decay
Poster
other (free) topics
Molecular studies of RNA-ER cotransport
Poster
other (free) topics
RNA localization is a widely utilized strategy employed by cells to spatially restrict protein function. In budding yeast, localized mRNAs form RNA-protein (RNP) complexes with the RNA-binding protein She2p that subsequently associate with the myosin motor protein Myo4p via the adaptor protein She3p (1). The Myo4p/She3p complex is also involved in inheritance of cortical endoplasmic reticulum (cER). To test for a functional link between mRNA localization and cER inheritance aux1 mutants where created since AUX1 is required for cER inheritance. However, although Aux1p localizes to ER membranes, its molecular role in ER inheritance remains elusive.(2)
Global identifiction of virulence-associated small non-coding RNAs in Yersinia pseudotuberculosis
Poster
RNA regulatory networks in prokaryotes
Trimodular Photoprobes – Isolation of small-molecule binding RNA by photoaffinity crosslinking
Poster
other (free) topics
Functional characterization of CRISPR-associated Cas1 protein of E. coli
Poster
other (free) topics
Affinity purification of mRNA-protein complexes
Poster
other (free) topics
First, we would like to establish a novel mRNP purification method from Saccharomyces cerevisiae and second, employ this method to study how the absence of RNA binding proteins such as RNA export factors influences mRNP formation. Our work should help to better understand the relationships between mRNP composition and function.
Implication of the non-coding E. coli 6S RNA in central metabolism
Poster
RNA-mediated regulation in transcription: emerging principles, RNA regulatory networks in prokaryotes
Development of tetracycline inducible self-cleaving RNA switches
Poster
Regulation via ligand-induced conformational changes
The RNA-binding protein Fox2 regulates adherens junction integrity in the developing cerebral cortex of the mouse embryo
Poster
Hot topics in regulation
The CRISPR/Cas system in Archaea: Molecular characterization of two conserved Cas complexes
Poster
Hot topics in regulation
Regulation of glmS expression in Escherichia coli: signaling within the hierarchically acting GlmYZ sRNA cascade is achieved by protein-sequestration
Poster
RNA regulatory networks in prokaryotes
Elucidating the role of TRBP in RNA interference
Poster
Mechanisms of micro-RNA function
RNA-based affinity purification of ncRNA-protein-complexes
Poster
other (free) topics
Synthesis of the regulatory RNA CsrC in Yersinia pseudotuberculosis is mediated by the RNA-binding protein CsrA, the nucleoid-associated proteins YmoA, H-NS and the RNA-chaperon Hfq
Poster
RNA regulatory networks in prokaryotes
Influence of RNA binding on the structure and functionality of Borna disease virus matrix protein
Poster
Regulation via ligand-induced conformational changes
Borna disease virus (BDV) is the causative agent for Borna disease, a non-cytolytic, persistent infection of the central nervous system detected originally among horses in Borna, Germany. The matrix protein of BDV (BDVM), a 16.2 kDa protein that forms homotetramers and octamers, is associated with virus assembly and budding and may also be associated with the regulation of the viral ribonucleoprotein activity. We have recently shown that BDVM binds single stranded RNA. Mutations in BDVM designed to abrogate specific RNA binding exhibit altered oligomerisation and RNA binding behaviour, and elicit potent growth attenuation in cell-based assays.
An in vivo map of Hfq binding sites in sRNAs and target mRNAs
Poster
RNA regulatory networks in prokaryotes
The small RNA RybA regulates the aromatic amino acid biosynthesis under oxidative stress
RNA regulatory networks in prokaryotes
Effect of the sRNA repeat RSs0680a-d on global gene regulation in Rhodobacter sphaeroides
Poster
RNA regulatory networks in prokaryotes
Identification and characterisation of proteins involved in riboregulation in Helicobacter pylori
Poster
other (free) topics
Functional analysis of microRNAs as regulators of secretory membrane trafficking
Poster
Mechanisms of micro-RNA function
Cellular distribution of intact siRNA
Poster
other (free) topics
Live-cell imaging of cells that get transfected with fluorescent labeled siRNA show the release of siRNA into the cytoplasm. Via two fluorescent dyes, the siRNA integrity inside cells can be deterimined by FRET.
Hunting 6S RNAs in Bacteria
Poster
other (free) topics
Customizable detection of ncRNA genes
Poster
other (free) topics
Jumonji domain-containing protein6 (Jmjd6) regulates the mRNA splicing of sFlt1 and thereby modulates angiogenesis
Poster
Hot topics in regulation
Functional analysis of small regulatory RNAs in Helicobacter pylori
Poster
RNA regulatory networks in prokaryotes
Structural dynamics of the human telomerase RNA pseudoknot
Poster
other (free) topics
The structural dynamics of the human telomerase RNA pseudoknot domain are investigated using single molecule fluorescence resonance energy transfer. Effects of Magnesium ions and the structural context are analyzed.
The primary transcriptome of the major human pathogen Helicobacter pylori
Poster
RNA regulatory networks in prokaryotes
Analysis of SyR1 - a sRNA regulating photosynthesis in Synechocystis sp. PCC6803
Poster
RNA regulatory networks in prokaryotes
Posttranscriptional regulation of the virulence regulator LcrF in Yersinia pseudotuberculosis
Poster
RNA regulatory networks in prokaryotes
Dual roles for the Mss116 cofactor during splicing of the ai5g group II intron
Poster
other (free) topics
6S RNA of cyanobacteria – an old issue became green
Poster
RNA regulatory networks in prokaryotes
RNAclust - an efficient RNA-clustering pipeline
Poster
other (free) topics
We present a software tool for global and local structure-based clustering of RNAs.
Functional characterisation of RNA helicases involved in ribosome biogenesis
Poster
Hot topics in regulation
Identification and characterization of small non-coding RNAs in the archaeal diazotroph Methanosarcina mazei Gö1
Poster
RNA regulatory networks in prokaryotes, other (free) topics
The role of Hfq in virulence of Shigella flexneri
Poster
RNA-mediated regulation in transcription: emerging principles, RNA regulatory networks in prokaryotes
Identification of sRNAs involved in antibiotic resistance in Salmonella.
Poster
RNA regulatory networks in prokaryotes
Use of RNA-seq to define sRNA regulation into the pathways controlling antibiotic resistance in Salmonella enterica serovar Typhimurium SL1344.
Revealing protein-RNA-interactions using RNA-immunopecipitation
Poster
RNA-mediated regulation in transcription: emerging principles
Functional characterisation of the novel protein-only RNase P from Arabidopsis thaliana – differences to ribozyme-based bacterial RNase P
Poster
other (free) topics
Aspergillus fumigatus induces microRNA-155 expression in vitro in human monocyte-derived dendritic cells
Poster
other (free) topics
The roles of small RNAs in regulatory networks
Invited Speaker
RNA regulatory networks in prokaryotes
THE HETEROGENEOUS RIBONUCLEOPROTEIN L-LIKE: ROLE IN ALTERNATIVE SPLICING REGULATION DURING IMMUNE CELL DEVELOPMENT
Poster
Hot topics in regulation
Assembly intermediates of the human and archaeal Signal Recognition Particle
Poster
Regulation via ligand-induced conformational changes
The paper includes two X-ray structures of SRP19/SRP-RNA complexes and describes an induced fit mechanism important for SRP assembly.
Active RNA cycling on Hfq
Invited Speaker
RNA regulatory networks in prokaryotes
Regulation of snoRNA transcription by DEAD box proteins Ddx5 and Ddx17
Poster
RNA-mediated regulation in transcription: emerging principles
mRNA decay mediated by the DEAD-box RNA helicase Ddx5
Poster
other (free) topics
RNA REGULATORY NETWORKS IN STAPHYLOCOCCUS AUREUS
Invited Speaker
RNA regulatory networks in prokaryotes
The contribution of RNAs in the regulation of gene expression required for stress response and the establishment of virulence of Staphylococcus aureus will be presented.
Conformational sampling by riboswitch aptamers
Invited Speaker
Regulation via ligand-induced conformational changes
The structural basis for ligand recognition by riboswitch aptamers with an emphasis on new insights into the structure of the unliganded state will be discussed.
Genomewide RNA binding of hnRNP L monitored by iCLIP: new role in noncoding RNA biogenesis?
Poster
Hot topics in regulation
Characterizing the loop-loop mutant of the guanine riboswitch
Poster
Regulation via ligand-induced conformational changes
Characterization of plant miRNAs and small RNAs derived from potato spindle tuber viroid (PSTVd) strains of different severity in infected tomato
Poster
Mechanisms of micro-RNA function
RNA binding and unwinding by the DEAD box protein Hera from Thermus thermorphilus
Poster
other (free) topics
Immunobiology of RIG-I
Invited Speaker
Hot topics in regulation
Expanding the Diversity of Noncoding RNA in Bacteria
Invited Speaker
Regulation via ligand-induced conformational changes
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