A network perspective on the biology of ageing

Over the past two decades, scientists have uncovered an impressive array of genes and gene pathways associated with longevity in laboratory organisms. However, ageing is a complex phenotype influenced by a large number of genetic and environmental factors. On closer inspection, we see that these the many genes associated with longevity interact with one another in a complex network of genes, proteins and metabolites. Moreover, although we have uncovered many genes that can alter lifespan in the laboratory, we are far from even a basic appreciation of the genes that underlie variation in longevity in natural populations, including humans. This presentation will explore how molecular networks can be used to understand the genetic basis of ageing in inbred laboratory organisms as well is in natural, genetically heterogeneous populations. Ultimately, network approaches will be critical to a full understanding of both the causes and consequences of ageing.